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马超美教授简介
马超美,女,内蒙古大学生命科学院生物系教授 Email: cmma@imu.edu.cn
本研究室欢迎对天然药物或功能食品研究有兴趣的的博士来做博士后。有以下研究经验之一者优先:1. 植物化学(或有机合成)研究经验。2. 药物代谢研究经验。博士后工资按在岗讲师待遇发放,津贴1万元/年,其它福利按内蒙古大学规定办。
研究活动:
1.植物成分的提取、分离和结构测定。
如:锁阳(Cynomorium
songaricum)、文冠木(Xanthoceras
sorbifolia)等中蒙药的生物活性成分研究。
2.植物成分衍生物及类似物的合成和生物活性研究。
如:绿原酸衍生物和类似物的制备及生物活性,三萜类化合物的结构改造及生物活性等。
3.植物成分体内外代谢研究。
如:生物碱的体内代谢产物的结构测定等。
教育:
1998.4-2001.3
日本富山医科药科大学(现与富山大学合并)药学博士
1996.4-1998.3 日本富山医科药科大学(现与富山大学合并)药学硕士
1979.9-1983.7 北京医学院药学系(现北京大学药学院)学士
工作经历:
2010.5- 内蒙古大学生命科学院生物系 教授
2006.7-2010.3 日本富山大学和汉医药学综合研究所 副教授
2003.3-2006.7 加拿大纽芬兰记念大学药学院 博士后
2001.5-2003.3 北京大学药学院 讲师-副教授
1994.4-1996.3 日本富山医科药科大学和汉药研究所
世川研修生-客员研究员
1983.8-1994.3
内蒙古医学院药学系 助教-讲师
部分论文:
1.
Ma, C. M.;
Kawahata, T.; Hattori, M.; Otake, T.;Wang, L.; Daneshtalab, M.
Synthesis, anti-HIV and anti-oxidant activities of caffeoyl
5,6-anhydroquinic acid derivatives. Bioorg Med Chem 18:
863-869 (2010).
2.
Ma, C. M.;
Sato, N.; Li, X. Y.; Nakamura, N.; Hattori, M. Flavan-3-ol contents,
anti-oxidative and
a-glucosidase
inhibitory activities of Cynomorium songaricum.
Food Chem 118:
116-119 (2010).
3.
Ma, C. M.;
Wei, Y.; Wang, Z. G.;
Hattori, M. Triterpenes from Cynomorium songaricum—analysis of
HCV protease inhibitory activity, quantification, and content change
under the influence of heating.
J Nat
Med
63:
9-14 (2009).
4.
Ma, C. M.;
Hattori, M.; Daneshtalab, M.; Wang, L. Chlorogenic Acid Derivatives with
Alkyl Chains of Different Lengths and Orientations: Potent
a-Glucosidase
Inhibitors. J Med Chem 51: 6188-6194 (2008).
5.
Ma, C. M.;
Hattori, M.; Chen, H. B.; Cai, S.-Q.; Daneshtalab, M.
Profiling the Phenolic Compounds of Artemisia pectinata by
HPLC-PAD-MSn.
Phytochem Analysis
19:
294-300 (2008).
6.
Ma, C. M.;
Kully, M.; Khan, J. K.; Hattori, M.; Daneshtalab, M. Synthesis of
chlorogenic acid derivatives with promising antifungal activity.
Bioorg Med Chem. 15: 6830-6833 (2007).)
7.
Ma, C. M.;
Winsor, L.; Daneshtalab, M.
Quantification of spiroether isomers and herniarin of different parts of
Matricaria matricarioides and flowers of Chamaemelum nobile.
Phytochem Analysis.
18:42-49
(2007).
8.
Ma, C. M.;
Takeda, S.;
Hibino, S.; Daneshtalab,
M. Synthesis of peptidomimetic analogues of echinocandines.
Heterocycles, 68: 721-732, (2006).)
9.
Ma, C. M.;
Cai, S. Q.; Cui, J. R.; Wang, R. Q.; Tu, P. F.; Hattori, M.;
Daneshtalab, M. The cytotoxic activity of ursolic acid derivatives.
Eur J Med Chem 40: 582-589 (2005).
10.
Ma, C. M.;
Nakamura, N.; Hattori, M.; Kakuda, H.; Qiao, J. C.; Yu, H.L.;
Inhibitory effects on HIV-1 protease of constituents from the wood of
Xanthoceras sorbifolia. J Nat Prod 63: 238-242 (2000).
11.
Ma, C. M.;
Nakamura, N.; Hattori, M.; Z. S.; Komatsu, K. Guaiane dimers and
germacranolide from Artemisia caruifolia. J Nat Prod 63:
1626-1629 (2000).
12.
Ma, C. M.;
Nakamura, N.; Miyashiro, H.; Hattori M.; Shimotohno, K.Inhibitory
effects of constituents from Cynomorium songaricum and related
triterpene derivatives on HIV-1 protease. Chem Pharm Bull 47:
141-145 (1999).
13.
Ma, C. M.;
Nakamura, N.; Hattori, M.
Saponins and C-glycosyl flavones from the seeds of Abrus
precatorius. Chem Pharml Bull 46: 982-987 (1998).
14. Wang,
W.;
Ma, C.
M.;
Hattori, M. Metabolism of isorhynchophylline
in rats detected by LC-MS.
JPPS
13:
27-37 (2010).
15. Wei,
Y.;
Ma, C. M.;
Hattori, M. Synthesis and evaluation of A-seco type
triterpenoids for anti-HIV-1 protease activity.
Eur J Med Chem
44:
4112-4120 (2009).
16. Sato,
N.;
Ma, C. M.;
Komatsu, K.; Hattori, M.
Triterpene-farnesyl
hydroquinone conjugates from
Ganoderma sinense.
J Nat Prod
72:
958-961 (2009).
17. Wei,
Y.;
Ma, C. M.;
Hattori, M. Synthesis of dammarane-type triterpene derivatives and their
ability to inhibit HIV and HCV proteases.
Bioorg Med Chem
17:
3003-3010 (2009).
18.
Phuong, D. T.;
Ma, C. M.;
Hattori, M.; Jin, J. S. Inhibitory
Effects of Antrodins A-E from Antrodia cinnamomea and Their
Metabolites on Hepatitis C Virus Protease.
Phytother Res
23:
582-584 (2009).
19. Yu,
J,;
Ma, C. M.;
Long, C. F.; Wang, X.; Shang, M. Y.; Cai, S. Q.; Hattori, M.; Namba, T.
A new aristololactam from
Asarum maximum. Journal of Chinese Pharmaceutical Sciences
18:
183–185 (2009).
20. Xu,
Q.;
Ma, C. M.;
Wang, W.; Fu, X.; Tang C. Y.; Hattori, M. Study on the nitric oxide
generating effects from aristolochic acid in vitro.
Eur J Mass Spectrom
14:
231-238(2008).
21. Wei
Y;
Ma, C. M.;
Chen D. Y; Hattori M.
Anti-HIV-1 protease triterpenoids from Stauntonia obovatifoliola
Hayata subsp. intermedia. Phytochemistry
69:
1875-1879 (2008).
22. Wang,
Z. G.;
Ma C. M.;
Tang, S. H.; Xiao, H,; Kakiuchi, N.; Kida, H.; Hattori, M.
Qualitative and Quantitative Analysis of Swertia Herbs by High
Performance Liquid Chromatography-Diode Array Detector-Mass Spectrometry
(HPLC-DAD-MS).
Chem Pharm Bull
56:
485-490 (2008).
23. Lee,
J. S.; Ma,
C. M.;
Park, D. K.; Yoshimi, Y.; Hatanaka, M.; Hattori, M. Transformation of
ergosterol peroxide to cytotoxic substances by rat intestinal bacteria.
Bio Pharm Bull
31: 949-54 (2008).
技术专利:
1.
Daneshtalab, Mohsen; Ma, Chao-Mei. Chlorogenic acid derivatives
and their use as antifungal agents. PCT Int. Appl. (2008), 77pp.
CODEN: PIXXD2 WO 2008009138 A1 20080124 AN 2008:94892.
2.
Daneshtalab, Mohsen; Ma, Chao-Mei; Stamp, Ronald J.
Reduced-hangover alcoholic beverage. PCT Int. Appl. (2008), 21pp.
CODEN: PIXXD2 WO 2008055348 A1 20080515 CAN 148:537052 AN
2008:590929.
3.
杜仲葉緑色乾燥粉末及びその製造方法 A23B 7/02 (2006.01) A23L 1/30 (2006.01) JPA23B7/02 A23L1/30 B )【発明者】安間 智慧子、服部 征雄、唐 淑含、王 志剛、馬 超美
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