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莫日根教授简介
Email：morigenm@life.imu.edu.cn 一、研究领域和兴趣： 1. DNA复制调控分子机理、基因表达、代谢和细胞周期。 DNA复制是个严格控制的细胞过程，与细胞周期的其它环节密切协调。复制起始的准确时空调控是一个正常细胞周期开始的必要条件。准确DNA复制使子细胞得到完整的遗传物质，以此将遗传信息从亲代完整的传给子代。本实验室主要以大肠杆菌为模式生物研究DNA复制调控分子机理，复制与基因表达、代谢和细胞周期其它环节之间的联系和协调。 2. 癌细胞DNA复制与基因组稳定性。 DNA复制差错或异常（过多或过少）复制会降低基因组稳定性，并由此可能引发细胞癌变或发育缺陷。根据2006年的统计，人细胞有165种蛋白质参与DNA复制，38种疾病与DNA复制差错有关。最近美国科学家发现干扰DNA复制起始负调控蛋白质Geminin的表达会选择性地抑制癌细胞生长。这对开发和发展抗癌药物意义重大。本实验室将逐步开展癌细胞DNA复制与基因组稳定性等方面的研究工作。 Research interests: 1. The Escherichia coli DNA replication and cell cycle. 2. DNA replication in cancer cells. 二、相关学术论文： 1．Weatherspoon-Griffin N, Zhao G, Kong W, Kong Y, Morigen, Andrews-Polymenis H, McClelland M, Shi Y. The CpxR/CpxA two-component system upregulates two Tat-dependent peptidoglycan amidases to confer bacterial resistance to antimicrobial peptide. J Biol Chem (2011), in press. 2．Line Johnsen, Ingvild Flåtten, Morigen, Bjørn Dalhus, Magnar Bjørås,Torsten Waldminghaus1 and Kirsten Skarstad. The G157C mutation in the Escherichia coli sliding clamp specifically affects initiation of replication. Mol Microbiol （2011）79(2):433-446 . 3. Odsbu I., Morigen and Skarstad K. A reduction in ribonucleotide reductase activity slows down the chromosome replication fork but does not change its localization. PLoS One (2009) 4(10):e7617.4. Wang, J. and Morigen BayesPI--a new model to study protein-DNA interaction: a case study of condition-specific protein binding parameters for yeast transcription factors. BMC Bioinformatics (2009) 10:345.5. Morigen, Odsbu I. and Skarstad K. Growth rate dependent numbers of SeqA structures organize the multiple replication forks in rapidly growing Escherichia coli.. Genes Cells (2009) 14:643-657.6. Flåtten I., Morigen and Skarstad K. DnaA protein interacts with RNA polymerase and protects it from the effect of rifampicin. Mol Microbiol (2009) 71(4):1018-1030 .7. Bach T., Morigen and Skarstad K. The initiator protein DnaA contributes to keeping new origins inactivated by promoting the presence of hemimethylated DNA. JMB (2008) 384(5):1076-85.8. Morigen, Molina F. and Skarstad K. Deletion of the datA site does not affect once-per-cell-cycle timing but induces rifampin-resistant replication. J Bacteriol (2005) 187(12):3913-20.9. Morigen, Løbner-Olesen A. and Skarstad K. Titration of the Escherichia coli DnaA protein to excess datA sites causes destabilization of replication forks, delayed replication initiation and delayed cell division. Mol Microbiol (2003) 50:349-362.10. Morigen, Boye E., Skarstad K., and Løbner-Olesen A. Regulation of chromosomal replication by DnaA protein availability in Escherichia coli: effects of the datA region. Biochim Biophys Acta (2001) 1521: 73-80.11. Weigel C., Messer W., Preiss S., Welzeck M., Morigen, Boye E. The sequence requirements for a functional Escherichia coli replication origin are different for the chromosome and a minichromosome. Mol Microbiol (2001) 40(2): 498-507.
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莫日根（Morigen），2005年毕业于挪威奥斯陆大学医学院分子生物学专业，获博士学位。之后在挪威肿瘤医院癌症研究所做博士后研究。2009年10月回国任内蒙古大学生命科学学院生物化学与分子生物学教授、博士生导师、内蒙古遗传学会副理事长、中国细胞生物学会理事、《中国生物化学与分子生物学报》编委。