IMU researchers make progress in livestock gene editing

A paper -- entitled Comparison of Gene Editing Efficiencies of CRISPR/Cas9 and TALEN for Generation of MSTN Knock-out Cashmere Goats – underscored progress being made by researchers in the gene editing of livestock, according to officials from Inner Mongolia University.

The paper was by a research team from IMU’s School of Life Science and the State Key Laboratory for Reproductive Regulation and Breeding of Grassland Livestock.

It was published in Theriogenology magazine, according to IMU officials.

CRISPR/Cas9 is the third generation of genome editing technology, which is an effective tool in scientific research, medical treatment and other fields.

In the IMU researchers’ study, the myostatin (MSTN) gene of a cashmere goat was systematically compared with the second generation gene editing technology -- called TALEN -- for site-specific mutations of the target gene, gene editing embryo development and gene editing animal production.

Researchers say CRISPR/Cas9 is more conducive to the production of gene edited animals.

They said the results of IMU’s study had laid the foundation for improving the efficiency of mammalian gene editing and using gene editing technology to cultivate new breeds of livestock.

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